Isles of Scilly Skybus is a British airline which operates domestic scheduled services to the Isles of Scilly from Land's End Airport and Newquay Airport in Cornwall, and from Exeter, Bristol and Southampton. The airline is owned by the Isles of Scilly Steamship Company which operates shipping services to the Isles of Scilly in its own name, and also owns Westward Airways.
The airline was established in March 1984 and started operations in August 1984. Isles of Scilly Skybus originated as an air charter operator at Land's End aerodrome operating high frequency services to the Isles of Scilly. Following the withdrawal of Brymon Airways routes to and from the islands the operator stepped in, initially operating services to Plymouth. This route was later dropped but with the addition of Twin Otter aircraft the route network expanded to its current make-up.

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